Psoriasis New

psoriasis new

Causes, symptoms and treatment of psoriasis

What is Psoriasis? Psoriasis is a chronic, common, recurrent skin disease Non-contagious lesions characterized by uneven red, gray or gray-white, dry scales, which are often painful, itchy and may bleed. The lesions are usually distributed symmetrically on the scalp, elbows, knees and essentially a part of the body. It disease with unpredictable and prone to relapses and remissions, which can affect the joints, nails and eyes [1, 2]. Psoriasis is found worldwide, but the prevalence varies among different ethnic groups. It affects 1-5% of Europeans overall, with rates as high only 6% in France and Germany. In the United Kingdom, it is the third most common dermatological diseases, affecting approximately 1-2% of the population, equivalent to about 1.2 million people and accounts for 10-20% of visits to a dermatology hospital [1, 3, 4]. It can strike both men and women, and starts young adults but it has been reported at birth. The average age of onset of the first presentation of psoriasis can vary 15 to 20 years, with a second peak occurring between the ages of 55-60 years.

Psoriasis is generally classified into one of three severities based on the extent of body surface covered. If 2% of the body is affected, it is classified as Benin, where 30-10% of the body is covered, it is classified as being moderate and more than 10% of the body is affected, the disease is classified as severe. Based on these criteria, approximately 25-30% of patients psoriasis, which is considered moderate to severe.

Causes or risk factors <- style1 {font-weight:. Bold; font-style: italic;} -> The exact cause of psoriasis is unknown, but many studies have attempted to identify risk factors for developing psoriasis. The following persons were identified as risk factors for development of psoriasis,

1. Family history (genetics)
It the main risk factor established for the development of psoriasis. About 40% of patients with psoriasis have a family history among parents in the first degree. It was also noted that psoriasis develops in nearly half of the siblings when both parents have psoriasis, this figure falls to 16% when only one parent is affected, and 8% if neither parent is affected, but there is an affected sibling.

2. Infections
Bacterial infections and viral infections may be linked to psoriasis, but beyond streptococcus, the role of other infections in the onset of psoriasis was not studied [4, 6].

3. Alcohol and smoking
Some studies have suggested that smoking or alcohol as a cause of psoriasis. Well much of these studies were case-control studies, based on a typical group of patients admitted to the hospital, in a study population-based, alcohol proved to be a major risk factor for mortality in patients with psoriasis. Not only this, alcohol has been associated with worsening of skin diseases after drinking among men and women and treatment failures. Alcohol appears to affect skin diseases like psoriasis by influencing the metabolism of dermal vasculature (arrangement of blood vessel around the skin), and immune response. Alcohol consumption can cause liver dysfunction, when the liver can not get rid of toxins as a result of this, various body systems are affected, including the skin. Skin, trying to purge itself of toxins may cause immune related disease such as psoriasis. It is quite possible that alcohol may alter the expression of psoriasis and its clinical course. Abstinence from alcohol can induce remission [4, 6, 8].

The role of smoking as a risk factor for psoriasis remains elusive. According to Neiman et al (2006) in 1992, researchers in the United Kingdom evaluated 108 patients with psoriasis and compared the rate of new with matched controls in the community. They showed a significant association between smoking "before the appearance" and psoriasis.

Although it has often been implicated in the pathogenesis and progression disease, conclusive data on the role of smoking is currently lacking. As indicated by some studies, whether or not the psoriasis stops the smoking probably does not alter the course of the disease [4, 6].

4. Trauma
Psoriasis may appear sites of trauma, including sites of sunburn after surgery or biopsy, or even after scraping a single region.

5. Stress
Recently, emphasis has been implicated in the acceleration or the acceleration the aggravation of psoriasis, as found in many other complex diseases in natural history. Although this factor has not been studied robust, the view that stress is an important factor in the natural history of psoriasis is widespread, particularly among groups of patients.

6. Drugs
Although exposure to the drug has not been well defined as a risk factor the incidence of new psoriasis, certain medications have been reported to aggravate pre-existing case of psoriasis. These drugs include lithium (a mood stabilizing drug) and antimalarials [4, 6].

Types of psoriasis <- style1 {font-style:!. Italic, font-weight: bold;} -> 1. Plaque psoriasis
This is the most common form of psoriasis characterized by strong circumscribed (confined or enclosed), round or oval-piece Business plates, with white rings bleaching observed in the skin surrounding the plates. The scales are usually present, typically gray-white, and may vary in thickness. The amount of these scales can vary the size from patient to patient and at different sites on a particular patient. Removal such a scale may be tiny bleeding points. Plaque psoriasis affects the back of the elbows and knees before and the back and leather Scalp (scalp psoriasis) [4, 5].

2. Guttate psoriasis
From the Greek word gutta drop, guttate psoriasis appears as small patches (2-10 mm in diameter) of psoriasis all over his body. Representing about 2% of all cases of psoriasis, it usually occurs shortly after a throat infection (Strep throat or tonsils) and may be the presenting episode of psoriasis in children and occasionally adults. The number stamp is evident in this type of psoriasis is variable and can range from 5 or 10 to over 100.

3. Flexural psoriasis
This affects the flexures (skin folds example, under the breasts), and lesions, which are devoid of scales and appear in red, shiny, well defined plaques.

4. Generalized pustular psoriasis
This is a rare type of psoriasis, which is active, unstable disease. It is characterized by Anti-inflammatory changes in psoriatic lesions and sites are shown as small circular patches of red, filled with pus. Patients present often a fever and usually require admission to hospital for management because it can be a fatal condition, with a variety implications, including hypothermia (dangerously low body temperature) [4, 5].

5. Erythrodermic psoriasis
It a rare but serious complication of psoriasis. It can take two forms,
psoriasis) chronic plaque, which can develop gradually as a confluence plates (running together) and extended, or
b) A demonstration of unstable psoriasis triggered by infection, tar, drugs, or withdrawal of corticosteroids (one synthetic drug similar or identical to a natural corticosteroid used to reduce inflammation and control disorder allergies).

It is one of the few emergencies involving skin conditions as it may hinder the ability of thermoregulation the skin, leading to hypothermia (dangerously low body temperature), a high output cardiac failure and metabolic changes such as anemia due to loss of iron and vitamin B12. Patients with this rare disease are usually admitted to hospital [4, 5].

6. Palmoplantar pustulosis
This presents as sterile, yellow pustules (small round raised area of ​​inflamed skin filled with pus) on a background Abnormally red skin caused by local congestion (as in inflammation) and wide, affecting the palms and / or soles. Pustules are soft and fade to form dark brown color with scales or crusts, which adhere to it. palmoplantar pustulosis most often affects women, This most often between the ages of 40 and 60 years and is associated with current smoking or past, up to 95% of subjects.

(It is now considered however that pustulosis palmoplatar can not be a form of psoriasis) [4, 5].

7. psoriatic nail disease
It usually affects nail polish that much. The most common finding is small sink (as a thimble) in the nail plate, resulting from the formation defective nails in the proximal (near the point of attachment) of the nail matrix. orange-yellow areas may also be present under the plate of the nail, it is called "oil spots". The plate of the nail may thicken, opaque and discolored.

Quality of life and psychological aspects of psoriasis does not usually affect survival, but it is important to consider the disease as a serious problem and to resist the tendency to underestimate its impact on the well-being of sufferers. It is a misconception that skin diseases are somehow less serious than other medical conditions, but the main negative effects on psoriasis has on patients is important and serious, it's demonstrable by a significant detriment to quality of life. Patients with psoriasis have a reduced quality of life very similar or even worse than patients with other chronic diseases such as heart disease (CHD) or diabetes [5, 16].

The disease not only complicates millions of lives, it also cripples countless relationships. Fouere et al (2005) mentions the fact that previous research has confirmed that over 80% of psoriasis patients have expressed difficulties in establishing social contacts and relationships being the worst aspect of their psoriasis. suffering from Psoriasis often feel stigmatized by the disease and that in itself contributes to the inability of all the days leading to depression and sometimes suicidal thoughts in more than 5% of patients. According to Langley et al (2005), recent studies have found that anxiety and pathological anxiety in at least third of patients with psoriasis. Psychological, interpersonal difficulties were also found to severely affect all aspects of life Daily patient. Engage in avoidance behaviors and the belief that they are valued on the basis of their skin disease, both contribute to stress in patients [3, 5].

The symptoms of psoriasis psoriasis symptoms vary depending on the type you have (see types of psoriasis). The The most common symptoms associated with most of plaque psoriasis include

1. Red patches of skin covered with silvery white scales frequently asked on the knees, elbows, trunk or scalp. They can become itchy, painful and sometimes crack and bleed.

2. Nail and nail may be affected, including discoloration and pitting of nails.

3. Small areas of bleeding where the skin is scratched.

4. The patients can sometimes suffer from arthritis (PsA see in diseases associated with them).

Psoriasis Treatment

There is no cure for psoriasis, treatment is yet to provide symptomatic relief and improved quality of life for patients. Strategies for treatment depend largely on the severity, location and extent of lesion coverage NETQUOTEVAR: 1. Current treatments include;

1. Sun exposure, which improves the appearance of psoriasis, particularly mild psoriasis.

2. creams and lotions may be prescribed, including topical steroids, dithranol, tar preparations, emollients, topical vitamin D3 analogues such as calcipotriol and tacalcitol and acid salicylic.

3. For moderate to severe psoriasis, which are generally less sensitive to the above, a more intense treatment are required in the form,

¢ prescribed drugs, including methotrexate, cyclosporin and acitretin.

¢ phototherapy (light therapy) as PUVA (psoralen and ultraviolet A), UVA, UVB and narrowband UVB beds.

¢ Herbs, Chinese herbs, homeopathic treatments

4. If triggered by throat infection, antibiotics will help.

These two links may help find a wide range of top quality products and they also have a comprehensive approach Learning Centres that will improve your well-being:

http://www.allergymatters.com/acatalog/Psoriasis_Learning_Centre.html

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About the Author

Dr Jawad Amjad MSc Kingston University

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